Plugable explains that native video outputs and DisplayLink displays can generally operate together on supported computers. The dock's USB graphics route does not normally switch off the built-in HDMI, DisplayPort, USB-C, or Thunderbolt video outputs. This can offer flexibility when arranging an existing workstation.

Native display limits still apply to native connections, while DisplayLink has its own software and product requirements. On a Mac, the relevant application and screen permissions remain necessary. Map each monitor's connection path in the setup record so a mixed dock arrangement can be checked without assuming every screen uses the same technology.